Preferred Label : SR-T100 Gel;
NCIt definition : A cutaneous gel preparation containing an extract from Solanum incanum with potential
antineoplastic activity. SR-T100 gel contains high amounts of the steroidal alkaloid
glycoside solamargine. Solamargine is able to upregulate expression of tumor necrosis
factor receptors 1 (TNFR1) and 6 (TNFRSF6 or Fas), and their signaling adaptors TNFR1-associated
death domain, and Fas-associated death domain. In addition, this agent is able to
upregulate expression of apoptosis promoter Bax, and suppress the expression of the
anti-apoptotic proteins Bcl-xL and Bcl-2. Altogether, this induces apoptosis in tumor
cells and may lead to an inhibition of tumor cell proliferation.;
Molecule name : SR-T100;
NCI Metathesaurus CUI : CL433216;
Origin ID : C99460;
UMLS CUI : C3274747;
Semantic type(s)
- concept_is_in_subset
