Preferred Label : Recombinant Oncolytic Poliovirus PVS-RIPO;
NCIt definition : A recombinant, live attenuated, nonpathogenic oncolytic virus containing the oral
poliovirus Sabin type 1 in which the internal ribosomal entry site (IRES) is replaced
with the IRES from human rhinovirus type 2 (HRV2), with potential antineoplastic activity.
Upon intratumoral administration of recombinant oncolytic poliovirus PVS-RIPO, the
poliovirus is selectively taken up by and replicates in tumor cells expressing CD155
(poliovirus receptor, PVR or NECL5) eventually causing tumor cell lysis. CD155, an
oncofetal cell adhesion molecule and tumor antigen, is ectopically expressed in certain
cancers, such as glioblastoma multiforme (GMB), and plays an important role in tumor
cell migration, invasion, and metastasis. Due to the heterologous HRV2 IRES in this
recombinant virus, PVS-RIPO only propagates in susceptible, nonneuronal cells (e.g.,
GBM).;
Molecule name : PVS-RIPO;
NCI Metathesaurus CUI : CL433215;
Origin ID : C99459;
UMLS CUI : C3274746;
Semantic type(s)
- Virus [UMLS semantic type]
- concept_is_in_subset
- has_target
