" /> Alanosine - CISMeF





Preferred Label : Alanosine;

NCIt synonyms : L-Alanosine Sodium; L-2-Amino-3-(hydroxynitrosoamino)propionic Acid; 3-(Hydroxynitrosoamino)-L-alanine; L-Alanosine;

NCIt related terms : L-2-Amino-3-[(N-nitroso)hydroxylamino]propionic acid; SDX-102;

NCIt definition : An amino acid analogue and antibiotic derived from the bacterium Streptomyces alanosinicus with antimetabolite and potential antineoplastic activities. L-alanosine inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate, an intermediate in purine metabolism. L-alanosine-induced disruption of de novo purine biosynthesis is potentiated by methylthioadenosine phosphorylase (MTAP) deficiency. The clinical use of this agent may be limited by its toxicity profile. MTAP is a key enzyme in the adenine and methionine salvage pathways.;

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antimetabolites.;

UNII : 2CNI71214Y;

InChIKey : MLFKVJCWGUZWNV-REOHCLBHSA-N;

CAS number : 5854-93-3;

Chemical formula : C3H7N3O4;

NSC code : 529469;

Codes from synonyms : NSC0529469; CDR0000322131; CDR0000322232;

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29/05/2025


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