P2RY8/CRLF2 Fusion Gene

Preferred Label : P2RY8/CRLF2 Fusion Gene;

NCIt synonyms : P2RY8-CRLF2 Fusion Gene; CRLF2/P2RY8 Fusion Gene; P2RY8::CRLF2 Fusion Gene;

NCIt definition : A fusion gene that results from an intrachromosomal deletion of the pseudoautosomal region 1of Xp22.3 and Yp11.3 which fuses the noncoding exon 1 of the P2RY8 gene to the entire coding region of the CRLF2 gene. This rearrangement is associated with Down syndrome-associated acute lymphoblastic leukemia.;

NCIt note : The P2RY8/CRLF2 gene fusion causes aberrant expression of the CRLF2 gene.;

GenBank Accession Number : GQ280263;

PubMed : 19838194;

Details

Origin ID

C99389;

UMLS CUI

C3275246;

Automatic exact mappings (from CISMeF team)
- Cytokine receptor-like factor 2 [OMIM gene]
- Pyrimidinergic receptor p2y, g protein-coupled, 8 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_has_abnormality
- Chromosomal Deletion [NCIt concept]
related_to_genetic_biomarker
- CRLF2 Gene [NCIt concept]
- P2RY8 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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