" /> Dexanabinol - CISMeF





Preferred Label : Dexanabinol;

NCIt synonyms : 1,1-Dimethylheptyl-11-hydroxytetrahydrocannabinol; 7-Hydroxy-delta-6-tetrahydrocannabinoldimethylheptyl;

NCIt definition : A synthetic, terpene-based cannabinoid derivative devoid of cannabinoid receptors 1 and 2 agonist activity and with potential neuroprotective, antiinflammatory and antineoplastic activities. Functioning as an N-Methyl-D-aspartate (NMDA) receptor antagonist, dexanabinol protects neuronal cells against NMDA and glutamate neurotoxicity. This agent also scavenges peroxy radicals and protects neurons from the damages of reactive oxygen species. Furthermore, dexanabinol inhibits the activity of nuclear factor kappa B (NF-kB), thereby preventing the expression of NF-kB target genes, such as tumor necrosis factor alpha, cytokines and inducible nitric oxide synthase. As a result, this agent may restore apoptotic processes in cancerous cells. NF-kB is activated in a variety of cancer cells and plays a key role in the regulation of apoptosis and cellular proliferation.;

UNII : R6VT8U5372;

InChIKey : SSQJFGMEZBFMNV-PMACEKPBSA-N;

CAS number : 112924-45-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 112924-45-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : HU-211;

Chemical formula : C25H38O3;

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12/05/2024


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