Preferred Label : Olaptesed Pegol;
NCIt definition : A 45-mer L-stereoisomer RNA oligonucleotide linked to a 40 kDa polyethyleneglycol
that targets the small chemokine stromal cell-derived factor 1 (SDF-1 or CXCL12) with
potential antineoplastic and hematopoietic stem cell-mobilization activities. SDF-1
targeted agent NOX-A12 specifically binds to SDF-1 thereby preventing the binding
of SDF-1 to its receptors CXCR4 and CXCR7 blocking the subsequent receptor activation.
This may prevent angiogenesis, tumor cell proliferation, invasion and metastasis and
could sensitize tumor cells to chemotherapy. In addition, inhibition of SDF-1/CXCR4
interaction may induce mobilization of hematopoietic cells from the bone marrow into
blood. The unique mirror-image configuration of this agent renders it resistant to
hydrolysis and does not hybridize with native nucleic acids. Furthermore, this agent
does not induce the innate immune response and has shown a favorable immunogenicity
profile.;
UNII : MTM792B442;
CAS number : 1390628-22-4;
Molecule name : NOX-A12;
Origin ID : C99379;
UMLS CUI : C4519190;
Semantic type(s)
- UMLS correspondences (same concept)
- NOX-A12 [MeSH Supplementary Concept]
- concept_is_in_subset
