Preferred Label : VEGFR-2 DNA Vaccine VXM01;
NCIt definition : An orally available DNA cancer vaccine containing an attenuated strain of the bacterium
Salmonella typhimurium encoding murine vascular endothelial growth factor receptor
2 (VEGFR-2) (VXM01), with potential immunomodulating, anti-angiogenic and antineoplastic
activity. Upon oral administration and successful transduction, VEGFR-2 DNA vaccine
VXM01 expresses VEGFR-2 in addition to inducing the expression of T-cell activation
markers, such as CD25, interleukin-2, the early T-cell activation antigen CD69 and
the lymphocyte function-associated antigen LFA-2. The immune response targets the
fast growing VEGFR-2 expressing endothelial cells found in the tumor vasculature,
thereby blocking angiogenesis which may ultimately inhibit tumor cell proliferation.
VEGFR-2 is a receptor tyrosine kinase overexpressed on proliferating endothelial cells
in the tumor vasculature.;
Molecule name : VXM01;
NCI Metathesaurus CUI : CL433162;
Origin ID : C99378;
UMLS CUI : C3274703;
Semantic type(s)
- concept_is_in_subset
