NCIt definition : A fusion gene that results from a chromosomal translocation t(11;22)(q13;q11) which
places the CCND1 gene on the 5' side of the immunoglobulin light chain locus IGLC1
gene. This rearrangement may be associated with numerous B-cell malignancies.;
NCIt note : This translocation allows the expression of the CCND1 gene to be controlled by the
IgG light chain promoter, which causes overexpression of the G1/S-specific cyclin-D1
protein.;