" /> CCND1/IGLC1 Fusion Gene - CISMeF





Preferred Label : CCND1/IGLC1 Fusion Gene;

NCIt synonyms : CCND1-IGLC1 Fusion Gene; CCND1::IGLC1 Fusion Gene;

NCIt definition : A fusion gene that results from a chromosomal translocation t(11;22)(q13;q11) which places the CCND1 gene on the 5' side of the immunoglobulin light chain locus IGLC1 gene. This rearrangement may be associated with numerous B-cell malignancies.;

NCIt note : This translocation allows the expression of the CCND1 gene to be controlled by the IgG light chain promoter, which causes overexpression of the G1/S-specific cyclin-D1 protein.;

NCI Metathesaurus CUI : CL433157;

PubMed : 8049438;

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07/05/2025


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