NPM1/ALK Fusion Protein

Preferred Label : NPM1/ALK Fusion Protein;

NCIt synonyms : NPM1-ALK Fusion Protein; NPM/ALK Fusion Protein; Nucleophosmin/ALK Tyrosine Kinase Receptor Fusion Protein; NPM-ALK Fusion Protein; NPM1::ALK Fusion Protein;

NCIt definition : A fusion protein (680 aa, 75 kDa) that is encoded by the NPM1/ALK fusion gene. This protein contains the N-terminal domain from the nucleophosmin protein and the cytoplasmic domain of the ALK tyrosine kinase receptor protein.;

NCIt note : The NPM1/ALK fusion protein is a constitutively dimerized and activated tyrosine kinase.;

Details

Origin ID

C99362;

UMLS CUI

C0541106;

Automatic exact mappings (from CISMeF team)
- p80(NPM-ALK) protein [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- p80(NPM-ALK) protein [MeSH Supplementary Concept]
- p80(NPM-ALK) protein [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Fusion Gene [NCIt concept]
- NPM1/ALK Fusion Gene [NCIt concept]
gene_product_plays_role_in_biological_process
- Tyrosine Phosphorylation [NCIt concept]
related_to_genetic_biomarker
- ALK Gene [NCIt concept]
- NPM1 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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