MLL/MLLT4 Fusion Gene

Preferred Label : MLL/MLLT4 Fusion Gene;

NCIt synonyms : MLL/AF6 Fusion Gene; MLL-MLLT4 Fusion Gene; MLL-AF6 Fusion Gene; AF6/MLL Fusion Gene; KMT2A-AFDN Fusion Gene; KMT2A/AFDN Fusion Gene; MLL::MLLT4 Fusion Gene; KMT2A::AFDN Fusion Gene;

NCIt definition : A fusion gene that results from a chromosomal translocation t(6;11)(q27;q23) which fuses the 5' half of the MLL gene to most of the MLLT4 gene. This rearrangement is associated with acute myeloid leukemia.;

NCIt note : The presence of this fusion gene is associated with a poor prognosis.;

Details

Origin ID

C99351;

UMLS CUI

C1834588;

Automatic exact mappings (from CISMeF team)
- Afadin [OMIM gene]
- Lysine-specific methyltransferase 2a [OMIM Phenotype]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- MLL/MLLT4 Fusion Protein [NCIt concept]
gene_has_abnormality
- t(6;11)(q27;q23) [NCIt concept]
gene_involved_in_molecular_abnormality
- t(6;11)(q27;q23) [NCIt concept]
gene_involved_in_pathogenesis_of_disease
- Acute Myeloid Leukemia with t(6;11)(q27;q23.3); MLLT4-KMT2A [NCIt concept]
gene_mapped_to_disease
- Acute Myeloid Leukemia with t(6;11)(q27;q23.3); MLLT4-KMT2A [NCIt concept]
related_to_genetic_biomarker
- AFDN Gene [NCIt concept]
- KMT2A Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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