MLL/AFF3 Fusion Gene

Preferred Label : MLL/AFF3 Fusion Gene;

NCIt synonyms : MLL-LAF4 Fusion Gene; LAF4/MLL Fusion Gene; MLL/LAF4 Fusion Gene; MLL-AFF3 Fusion Gene; KMT2A::AFF3 Fusion Gene; MLL::AFF3 Fusion Gene;

NCIt definition : A fusion gene that results from a chromosomal translocation t(2;11)(p15;q23) which fuses the 5' half of the MLL gene to the 3' half of the AFF3 gene. This rearrangement is associated with acute lymphocytic leukemia and other leukemia types.;

NCIt note : The patients with this fusion gene also had other chromosomal rearrangements.;

Details

Origin ID

C99341;

UMLS CUI

C1834585;

Automatic exact mappings (from CISMeF team)
- Alf transcription elongation factor 3 [OMIM gene]
- Lysine-specific methyltransferase 2a [OMIM Phenotype]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- MLL/AFF3 Fusion Protein [NCIt concept]
related_to_genetic_biomarker
- AFF3 Gene [NCIt concept]
- KMT2A Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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