MLL/ABI1 Fusion Gene

Preferred Label : MLL/ABI1 Fusion Gene;

NCIt synonyms : ABI1/MLL Fusion Gene; MLL-ABI1 Fusion Gene; KMT2A::ABI1 Fusion Gene; MLL::ABI1 Fusion Gene;

NCIt definition : A fusion gene that results from a chromosomal translocation t(10;11)(p11.2;q23) which fuses either exon 6 or 7 of the MLL gene to nucleotide 433 of the ABI1 gene. This rearrangement is associated with acute monoblastic leukemia, acute myelomonocytic leukemia and acute myeloid leukemia;

Details

Origin ID

C99339;

UMLS CUI

C1864215;

Automatic exact mappings (from CISMeF team)
- Abl interactor 1 [OMIM gene]
- Lysine-specific methyltransferase 2a [OMIM Phenotype]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- MLL/ABI1 Fusion Protein [NCIt concept]
gene_involved_in_molecular_abnormality
- t(10;11)(p11.2;q23) [NCIt concept]
related_to_genetic_biomarker
- ABI1 Gene [NCIt concept]
- KMT2A Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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