KMT2A/MLLT3 Fusion Gene

Preferred Label : KMT2A/MLLT3 Fusion Gene;

NCIt synonyms : MLL/AF9 Fusion Gene; MLL-AF9 Fusion Gene; MLL-MLLT3 Fusion Gene; KMT2A::MLLT3 Fusion Gene; MLL::MLLT3 Fusion Gene; MLL/MLLT3 Fusion Gene;

NCIt definition : A fusion gene that results from a chromosomal translocation t(9;11)(p22;q23) which fuses the 5' half of the KMT2A gene to the 3' end of the MLLT3 gene. This rearrangement is associated with acute lymphocytic leukemia and other leukemia types.;

NCIt note : The presence of this fusion gene is associated with a better prognosis for primary leukemia as compared to other 11q23 fusions but it indicates a poor prognosis for secondary cases. (Atlas of Genetics and Cytogenetics in Oncology and Haematology);

Details

Origin ID

C99323;

UMLS CUI

C3274681;

Automatic exact mappings (from CISMeF team)
- Lysine-specific methyltransferase 2a [OMIM Phenotype]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- MLL/MLLT3 Fusion Protein [NCIt concept]
gene_has_abnormality
- t(9;11)(p21.3;q23.3) [NCIt concept]
gene_involved_in_molecular_abnormality
- MLLT3-KMT2A Fusion Protein Expression [NCIt concept]
- t(9;11)(p21.3;q23.3) [NCIt concept]
gene_involved_in_pathogenesis_of_disease
- Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A [NCIt concept]
gene_mapped_to_disease
- Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A [NCIt concept]
- Adult Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A [NCIt concept]
- Childhood Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A [NCIt concept]
- Recurrent Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A [NCIt concept]
related_to_genetic_biomarker
- KMT2A Gene [NCIt concept]
- MLLT3 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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