NCIt definition : A fusion gene that results from a cryptic chromosomal rearrangement of chromosome
19 which fuses either exon 13 or 14 of the TCF3 gene with part of the TFPT gene. This
rearrangement is associated with childhood pre-B cell acute lymphoblastic leukemia.;
NCIt note : The TCF3/TFPT fusion gene junction is in frame in some cases, and out of frame in
others. Putative protein products would contain the N-terminal transactivation domains
of the transcription factor E2-alpha protein and very few amino acids from the TCF3
fusion partner protein because of the frequent occurrence of a stop codon. (Atlas
of Genetics and Cytogenetics in Oncology and Haematology);