" /> TCF3/TFPT Fusion Gene - CISMeF





Preferred Label : TCF3/TFPT Fusion Gene;

NCIt synonyms : TCF3-TFPT Fusion Gene; E2A/TFPT Fusion Gene; TFPT/E2A Fusion Gene; E2A/FB1 Fusion Gene; E2A-TFPT Fusion Gene; TCF3::TFPT Fusion Gene;

NCIt definition : A fusion gene that results from a cryptic chromosomal rearrangement of chromosome 19 which fuses either exon 13 or 14 of the TCF3 gene with part of the TFPT gene. This rearrangement is associated with childhood pre-B cell acute lymphoblastic leukemia.;

NCIt note : The TCF3/TFPT fusion gene junction is in frame in some cases, and out of frame in others. Putative protein products would contain the N-terminal transactivation domains of the transcription factor E2-alpha protein and very few amino acids from the TCF3 fusion partner protein because of the frequent occurrence of a stop codon. (Atlas of Genetics and Cytogenetics in Oncology and Haematology);

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08/05/2025


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