TCF3/HLF Fusion Gene

Preferred Label : TCF3/HLF Fusion Gene;

NCIt synonyms : E2A-HLF Fusion Gene; TCF3-HLF Fusion Gene; E2A/HLF Fusion Gene; HLF/E2A Fusion Gene; TCF3::HLF Fusion Gene;

NCIt definition : A fusion gene ( 4.4 kb) that results from a chromosomal translocation t(17;19)(q22;p13) which fuses intron 13 of the TCF3 gene with intron 3 of the HLF gene. This rearrangement is associated with childhood pre-B cell acute lymphoblastic leukemia.;

GenBank Accession Number : M95586;

Details

Origin ID

C99289;

UMLS CUI

C1840636;

Automatic exact mappings (from CISMeF team)
- Hepatic leukemia factor [OMIM gene]
- Transcription factor 3 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- TCF3/HLF Fusion Protein [NCIt concept]
gene_has_abnormality
- t(17;19)(q22;p13) [NCIt concept]
gene_involved_in_molecular_abnormality
- t(17;19)(q22;p13) [NCIt concept]
gene_involved_in_pathogenesis_of_disease
- B Acute Lymphoblastic Leukemia with TCF3-HLF Rearrangement [NCIt concept]
gene_mapped_to_disease
- B Acute Lymphoblastic Leukemia with TCF3-HLF Rearrangement [NCIt concept]
- B Lymphoblastic Leukemia/Lymphoma with TCF3-HLF Rearrangement [NCIt concept]
gene_plays_role_in_process
- Transcriptional Activation [NCIt concept]
related_to_genetic_biomarker
- HLF Gene [NCIt concept]
- TCF3 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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