Preferred Label : Anti-EGFRvIII Antibody Drug Conjugate AMG 595;
NCIt synonyms : Anti-EGFRvIII-DM1 Immunoconjugate AMG 595;
NCIt definition : An immunoconjugate consisting of a human monoclonal antibody directed against the
deletion-mutant of epidermal growth factor receptor, EGFRvIII, conjugated via a non-cleavable
linker to the cytotoxic agent maytansinoid DM1, with potential antineoplastic activity.
The monoclonal antibody moiety of this immunoconjugate binds to EGFRvIII on tumor
cell surfaces. After internalization, the DM1 moiety binds to tubulin, thereby disrupting
microtubule assembly/disassembly dynamics and inhibiting cell division and the proliferation
of cancer cells that express the EGFRvIII mutant. EGFRvIII, a deletion mutation of
exons 2-7 in the epidermal growth factor receptor gene, is overexpressed by a variety
of cancers, including glioblastoma multiforme, non-small lung carcinoma, and breast
carcinoma.;
Molecule name : AMG 595;
Origin ID : C99222;
UMLS CUI : C3274618;
Currated CISMeF NLP mapping
- AMG 595 [MeSH Supplementary Concept]
- Semantic type(s)
- UMLS correspondences (same concept)
- AMG 595 [MeSH Supplementary Concept]
- concept_is_in_subset
- has_target
