Preferred Label : Allogeneic CD19-specific CAR-modified CD8 Plus Central Memory-derived Virus-specific
T Cells;
NCIt synonyms : Allogeneic CD19CAR-TCM Cells;
NCIt definition : A preparation of allogeneic Epstein-Barr virus (EBV)- and human cytomegalovirus (CMV)-specific
CD8 central memory-derived T effector-lymphocytes that have been genetically modified
to express a chimeric antigen receptor (CAR) anti-CD19/CD3 zeta chain fusion protein
coupled to the intracellular signal domain of CD28 antigen, with potential immunostimulating,
anti-viral and antineoplastic activities. Upon infusion, allogeneic CD19-specific
CAR-modified CD8 central memory-derived virus-specific T cells directs the T-lymphocytes
to CD19-expressing tumor cells, stimulating a selective toxicity to tumor cells which
may eventually result in tumor cell lysis. CD19 antigen is a B-cell specific cell
surface antigen expressed in all B-cell lineage malignancies. The viral specific T-cells
exert antiviral immunity.;
NCI Metathesaurus CUI : CL433046;
Origin ID : C99215;
UMLS CUI : C3274612;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
