Preferred Label : Indium In 111 Anti-EGFR Monoclonal Antibody ABT-806;
NCIt synonyms : Indium In 111 ABT-806; 111-Indium-ABT806; Indium 111 ABT-806;
NCIt related terms : ABT-806I;
NCIt definition : A radioimmunoconjugate composed of a humanized monoclonal antibody IgG1 directed against
the epidermal growth factor receptor (EGFR) and labeled with the radioisotope indium
In 111, with potential radioimaging activity. Indium In 111 anti-EGFR monoclonal antibody
ABT-806 binds to a specific epitope of either wild-type or EGFR variant III mutant
on tumor cells, thereby allowing imaging of EGFR-expressing tumor cells using gamma
scintigraphy. ABT-806 is the humanized version derived from the predecessor chimeric
monoclonal antibody 806. EGFR, a receptor tyrosine kinase overexpressed on the cell
surfaces of many tumor cell types, plays a key role in tumor cell proliferation.;
UNII : IL87IM9EMV;
NCI Metathesaurus CUI : CL433018;
Origin ID : C99169;
UMLS CUI : C3274582;
Semantic type(s)
- concept_is_in_subset
- has_target
