Preferred Label : Yttrium Y 90 Tabituximab Barzuxetan;
NCIt synonyms : OTSA101-DTPA-90Y; 90Y Tabituximab Barzuxetan; Yttrium Y 90-labeled Anti-FZD10 Monoclonal Antibody OTSA101;
NCIt definition : A radioimmunoconjugate composed of a humanized monoclonal antibody (MoAb) OTSA101
against FZD10 and labeled with yttrium y 90, with potential antineoplastic activity.
The MoAb moiety of yttrium Y 90-labeled anti-FZD10 monoclonal antibody OTSA101 binds
to FZD10, thereby delivering a cytotoxic dose of beta radiation to FZD10 positive
tumor cells. FZD10 (also called CD350), a member of the Frizzled family of G protein-coupled
receptors that is involved in the Wnt/beta-catenin/TCF signaling pathway, is overexpressed
in a variety of cancer cell types but undetectable in normal, healthy human tissues
except for the placenta.;
NCI Metathesaurus CUI : CL433017;
Origin ID : C99168;
UMLS CUI : C5421255;
Semantic type(s)
- concept_is_in_subset
