NCIt definition : A polypeptide derived from the Salmonella filament protein flagellin with potential
radioprotective and anticancer activities. As a toll-like receptor 5 (TLR5) agonist,
entolimod binds to and activates TLR5 thereby stimulating tumor necrosis factor production
and activating nuclear factor kappa B (NF-kB). This induces NF-kB-mediated signaling
pathways and inhibits the induction of apoptosis. This may prevent apoptosis in normal,
healthy cells during radiotherapy of cancerous cells and may allow for increased doses
of ionizing radiation. In addition, entolimod may inhibit radiation-independent proliferation
in TLR5-expressing tumor cells.;
Currated CISMeF NLP mapping