Preferred Label : DNA-dependent Protein Kinase-targeting siDNA DT01;
NCIt synonyms : DNA-PK-targeting siDNA DT01;
NCIt definition : A proprietary preparation of small interfering DNA (siDNA) molecules with potential
chemo/radiosensitizing activity. By mimicking DNA double strand breaks (DSBs), DNA-dependent
protein kinase-targeting siDNA DT01 inhibits the non-homologous end joining (NHEJ)
process, one of the main DNA repair mechanisms, via binding to and activating DNA-dependent
protein kinase (DNA-PK), a core component of the NHEJ complex. DNA-PK activation causes
hyper-phosphorylation of histone variant H2AX on DNA and results in a different phosphorylated
pattern of H2AX upon ionizing radiation treatment. This ultimately interferes with
the repair of DNA DSBs during chemo- or radiotherapy, thereby increasing tumor cell
death. The enhanced ability of tumor cells to repair DSBs plays a major role in the
resistance of tumor cells to chemo- and radiotherapy.;
Molecule name : DT01;
NCI Metathesaurus CUI : CL433015;
Origin ID : C99165;
UMLS CUI : C3274579;
Semantic type(s)
- concept_is_in_subset
