Preferred Label : Lyophilized Black Raspberry Lozenge;
NCIt synonyms : LBR Lozenge; Black Raspberry Confection; BRB Confection;
NCIt definition : A lozenge containing lyophilized black raspberry with potential antioxidant, pro-apoptotic,
anti-angiogenic and chemopreventive activities. In addition to vitamins, minerals
and phytosterols, black raspberries are rich in phenolic acids, such as gallic acid,
ellagic acid, proanthocyanidins, and flavonoids. The anthocyanins appear to contribute
significantly to this agent's effects. Anthocyanins inhibit both the activation of
several signal transduction pathways, including the mitogen-activated protein kinase-mediated
pathways, and certain transcription factors, such as nuclear factor kappa B (NF-kB),
activator protein-1 (AP-1) complex, and nuclear factor in activated T-cells (NFAT).
This inhibitory activity modulates the expression of downstream target genes that
are upregulated in a variety of cancer cell types, including inducible nitric oxide
synthase, cyclooxygenase-2, vascular endothelial growth factor and the anti-apoptotic
protein survivin.;
NCI Metathesaurus CUI : CL433013;
Origin ID : C99163;
UMLS CUI : C3274577;
Semantic type(s)
- concept_is_in_subset
