Preferred Label : Monoclonal Antibody AbGn-7;
NCIt synonyms : AbGn-7;
NCIt definition : A chimeric monoclonal antibody against a Lewis-A-like glycotope (AbGn-7 antigen) with
potential immunomodulating and antineoplastic activities. Monoclonal antibody AbGn-7
targets and binds to the carbohydrate AbGn-7 antigen on the cell surface of tumor
cells and may induce complement-dependent cytotoxicity (CDC) and antibody-dependent
cell-mediated cytotoxicity (ADCC), thereby killing AbGn-7-epitope positive tumor cells.
AbGn-7 antigen is expressed on a variety of tumor cell types, including human colorectal,
pancreatic and gastric tumor cells.;
NCI Metathesaurus CUI : CL433012;
Origin ID : C99162;
UMLS CUI : C3274576;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
