Preferred Label : Tri-virus/GD2-specific Allogeneic Cytotoxic T-lymphocytes;
NCIt definition : Allogeneic tri-viral specific, Epstein-Barr virus (EBV), cytomegalovirus (CMV) and
adenovirus (Ad), cytotoxic T-lymphocytes (tV-CTLs) expressing a chimeric antigen receptor
(CAR) specific for disialoganglioside GD2 with potential antineoplastic activity.
Tri-virus/GD2-specific allogeneic CTLs are produced by transducing tV-CTLs with a
GD2-specific CAR retroviral vector. Upon administration, after an allogeneic hematopoietic
stem cell transplant, these CTLs may be selective towards EBV, CMV, and Ad-infected
cells and GD2-expressing tumor cells. The human glycosphingolipid GD2 is a tumor associated
antigen overexpressed on the surface of all tumors of neuroectodermal origin.;
NCI Metathesaurus CUI : CL432950;
Origin ID : C99132;
UMLS CUI : C3274553;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
