Preferred Label : AIM2(-1)/HT001(-1)/TAF1B(-1) Frameshift Peptide Vaccine;
NCIt synonyms : AIM2(-1)/HT001(-1)/TAF1B(-1) FSP Vaccine;
NCIt definition : A cancer vaccine containing the three frame shift peptides (FSP) AIM2(-1), HT001(-1)
and TAF1B(-1), with potential immunomodulating activity. Upon administration, the
AIM2(-1)/HT001(-1)/TAF1B(-1) FSP vaccine may induce an immune response against microsatellite
instability (MSI) colorectal cancer-associated antigens. Frame shift mutations of
AIM2 (absent in melanoma 2, an interferon-inducible protein), HT001 (asteroid homolog
1 or ASTE1, with an unknown function) and TAF1B (TATA box-binding protein-associated
RNA polymerase I B, a transcription factor) are seen in MSI-positive colorectal cancers
and may be associated with malignant transformation, tumor progression and the presence
of tumor-infiltrating lymphocytes. These FSPs all have one-base deletions.;
NCI Metathesaurus CUI : CL432947;
Origin ID : C99129;
UMLS CUI : C3274550;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
