Preferred Label : cis-Urocanic Acid;
NCIt synonyms : cis-UCA;
NCIt definition : A derivative of the amino acid histidine, formed in the mammalian skin from trans-urocanic
acid upon ultraviolet radiation, and protodynamic agent, with potential anti-inflammatory
and antiproliferative activity. Upon intravesical instillation of cis-urocanic acid
(cis-UCA), this agent is protonated at the imidazolyl moiety in the mildly acidic
extracellular tumor environment and penetrates into the cancer cell. Once inside the
cell and due to the slightly alkaline pH inside the tumor cell, cis-UCA is deprotonated,
i.e. the imidazolyl proton is released into the cytosol which eventually raises the
intracellular acidity. This acidification impairs many cellular processes, such as
metabolic activity, and may lead to cell cycle arrest, an induction of cellular apoptosis
and necrotic cell death. In addition, cis-UCA enhances ERK and JNK signaling pathways
by inhibiting the activity of serine/threonine and tyrosine phosphatases.;
UNII : 5LM7WD7VIC;
CAS number : 7699-35-6;
NCI Metathesaurus CUI : CL432945;
ChEBI ID : CHEBI:30818;
Origin ID : C99125;
UMLS CUI : C3274548;
Semantic type(s)
- concept_is_in_subset
