" /> Mericitabine - CISMeF





Preferred Label : Mericitabine;

NCIt synonyms : 3',5'-diisobutyryl PSI 6130; 2' alpha-fluoro-2' beta-methyl-3',5'-diisobutyryldeoxycytidine; PSI 6130 Diisobutyrate; 2'-deoxy-2'-fluoro-2'-c-methylcytidine Diisobutyrate;

NCIt definition : An orally available prodrug of PSI-6130 which is a selective cytidine nucleoside analogue and non-cytotoxic hepatitis C virus (HCV) polymerase inhibitor. After intracellular uptake, mericitabine is phosphorylated into two active triphosphate metabolites, which disable HCV RNA-dependent RNA polymerase (non-structural protein 5B; NS5B) upon binding. This results in the blockage of viral HCV RNA production and thus viral replication. This agent has a high barrier to resistance, however, a substitution mutation (S282T) on HCV NS5B impairs mericitabine's activity significantly.;

UNII : TA63JX8X52;

InChIKey : MLESJYFEMSJZLZ-MAAOGQSESA-N;

CAS number : 940908-79-2;

Molecule name : RG 7128; R7128; RO-5024048;

Chemical formula : C18H26FN3O6;

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19/06/2025


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