" /> Serabelisib - CISMeF





Preferred Label : Serabelisib;

NCIt synonyms : MLN1117; (6-(2-Amino-5-benzoxazolyl)imidazo(1,2-a)pyridin-3-yl)-4-morpholinylmethanone;

NCIt definition : An orally bioavailable inhibitor of the class I phosphoinositide 3-kinase (PI3K) alpha isoform with potential antineoplastic activity. Serabelisib selectively inhibits PI3K alpha kinase, including mutations of PIK3CA, in the PI3K/Akt/mTOR pathway, which may result in tumor cell apoptosis and growth inhibition in PI3K alpha-expressing tumor cells. By specifically targeting class I PI3K alpha, this agent may be more efficacious and less toxic than pan PI3K inhibitors. Dysregulation of the PI3K/Akt/mTOR pathway is frequently found in solid tumors and results in promoting tumor cell growth, survival, and resistance to chemotherapy and radiotherapy; PIK3CA, one of the most highly mutated oncogenes, encodes the p110-alpha catalytic subunit of the class I PI3K.;

UNII : 43J9Q56T3W;

InChIKey : BLGWHBSBBJNKJO-UHFFFAOYSA-N;

CAS number : 1268454-23-4;

Molecule name : INK1117; TAK-117; MLN-1117; TAK 117;

NCI Metathesaurus CUI : CL432860;

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08/05/2025


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