Aclacinomycin Antitumor Antibiotic

Preferred Label : Aclacinomycin Antitumor Antibiotic;

NCIt synonyms : Aclacinomycins; Aclacinomycin Antibiotic; aAclacinomycin;

NCIt definition : An oligosaccharide anthracycline antibiotic isolated from strains of the bacterium Streptomyces galilaeus with potential antineoplastic activity. These agents display potent antitumor properties due to their ability to intercalate into DNA and interfere with the function of both the topoisomerase I and II enzymes, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis.;

CAS number : 66676-88-8;

Details

Origin ID

C987;

UMLS CUI

C0919315;

Automatic exact mappings (from CISMeF team)
- Aclarubicin [SMS substance]
- aclacinomycin [MeSH concept]
- aclarubicin [MeSH Descriptor]
Currated CISMeF NLP mapping
- aclacinomycins [MeSH concept]
- aclacinomycins [MeSH Supplementary Concept]
Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- aclacinomycins [MeSH concept]
- aclacinomycins [MeSH Supplementary Concept]

Keyword's position in hierarchy(ies) :

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