Preferred Label : Acitretin;
NCIt synonyms : Etretin; Trimethylmethoxyphenyl-retinoic acid; (All-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic Acid;
NCIt definition : An orally-active metabolite of the synthetic aromatic retinoic acid agent etretinate
with potential antineoplastic, chemopreventive, anti-psoratic, and embryotoxic properties.
Acitretin activates nuclear retinoic acid receptors (RAR), resulting in induction
of cell differentiation, inhibition of cell proliferation, and inhibition of tissue
infiltration by inflammatory cells. This agent may also inhibit tumor angiogenesis.
(NCI04);
Alternative definition : NCI-GLOSS: A substance that is used in the prevention of cancer and in the treatment
of psoriasis. It belongs to the family of drugs called retinoids.;
UNII : LCH760E9T7;
InChIKey : IHUNBGSDBOWDMA-AQFIFDHZSA-N;
CAS number : 55079-83-9;
Drug name : Neotigason; Soriatane;
Molecule name : Ro-10-1670; Ro 10-1670;
Chemical formula : C21H26O3;
ChEBI ID : CHEBI:50173;
Codes from synonyms : 30398; CDR0000046118;
Origin ID : C985;
UMLS CUI : C0050559;
Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
