NCIt definition : A derivative of D-glucaro-1, 4-lactone with chemopreventive and anti-tumor activities.
One of the key processes in which human body eliminates toxic chemicals as well as
hormones (such as estrogen) is by glucuronidation. When beta-glucuronidase deconjugates
these glucuronides, it prolongs the stay of the hormone or toxic chemical in the body.
Elevated beta-glucuronidase activity has been implicated to be associated with an
increased risk for hormone-dependent cancers like breast, prostate, and colon cancers.
Thereby, aceglatone may suppress the developments of hormone-dependent cancers mediated
through beta-glucuronidase inhibition.;