Preferred Label : Ebselen-containing Oral Capsule SPI-1005;
NCIt definition : An oral capsule containing a proprietary formulation of the organoselenium compound
ebselen, with potential anti-oxidant, anti-inflammatory and cytoprotective activity.
Upon oral administration of SPI-1005, this agent mimics the activity of glutathione
peroxidase (GPx) and can utilize glutathione to reduce other unstable molecules, thus
preventing the formation of reactive oxygen species (ROS) and reducing oxidative stress
on the cell. In the cochlea, this agent may prevent drug-induced injury to the auditory
hair cells thereby preventing hearing loss. GPx is the main antioxidant enzyme in
the cochlea and protects the inner ear from loud sounds and biochemical damage. In
addition, ebselen is able to inhibit the activity of many enzymes involved in inflammation.;
Molecule name : SPI-1005;
NCI Metathesaurus CUI : CL432490;
Origin ID : C98398;
UMLS CUI : C3274045;
Semantic type(s)
- concept_is_in_subset
