NCIt definition : A pseudotetrasaccharide and inhibitor of alpha-glucosidase and pancreatic alpha-amylase
with antihyperglycemic activity. Acarbose binds to and inhibits alpha-glucosidase,
an enteric enzyme found in the brush border of the small intestines that hydrolyzes
oligosaccharides and disaccharides into glucose and other monosaccharides. This prevents
the breakdown of larger carbohydrates into glucose and decreases the rise in postprandial
blood glucose levels. In addition, acarbose inhibits pancreatic alpha-amylase which
hydrolyzes complex starches to oligosaccharides in the small intestines.;