Preferred Label : Anti-c-fms Monoclonal Antibody AMG 820;
NCIt related terms : AMG-820;
NCIt definition : A fully human IgG2 monoclonal antibody against the colony-stimulating factor-1 (CSF-1
or M-CSF) receptor c-fms (or CSFR1), with potential antineoplastic activity. Upon
administration, anti-c-fms monoclonal antibody AMG 820 binds to and blocks c-fms,
thereby blocking CSF-1 binding to its receptor and suppressing CSF-1-induced c-fms
signaling. This results in the suppression of recruitment and activation of tumor
associated macrophages (TAM) within the tumor microenvironment. This eventually leads
to a decrease in tumor growth. c-fms, a transmembrane protein belonging to the tyrosine
kinase family, is overexpressed in certain tumor cell types and plays an essential
role in macrophage differentiation and regulation of cell proliferation. The presence
of TAM is correlated with tumor proliferation, invasion and a poor prognosis.;
UNII : SZ3778HS3S;
CAS number : 2243120-07-0;
Molecule name : AMG 820;
NCI Metathesaurus CUI : CL432413;
Origin ID : C98295;
UMLS CUI : C3273946;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
