Preferred Label : GM-CSF-encoding Oncolytic Adenovirus CGTG-102;
NCIt definition : A recombinant, oncolytic serotype 5/3 capsid-modified adenovirus encoding the immunostimulatory
cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) with potential
antineoplastic activity. Upon administration, the oncolytic adenovirus selectively
infects and replicates in tumor cells, which may result in tumor cell lysis. Synergistically,
GM-CSF (sargramostim) expressed by the oncolytic adenovirus enhances antigen presentation,
promotes natural killer (NK) cell-mediated killing and causes a cytotoxic T cell (CTL)
response against tumor cells harboring the oncolytic adenovirus, resulting in an immune-mediated
tumor cell death. CGTG-102 is designed to replicate only in cells with defects in
the p16/Rb/E2F pathway, attributed to a mutation common in many solid tumors. Replacement
of the Ad5 capsid protein knob with a knob domain from serotype 3 causes higher transduction
in cancer cells as compared to normal cells.;
Molecule name : CGTG-102; ONCOS-102;
NCI Metathesaurus CUI : CL432405;
Origin ID : C98287;
UMLS CUI : C3273938;
Semantic type(s)
- concept_is_in_subset
