Preferred Label : Allogeneic GM-CSF-secreting Lethally Irradiated Whole Melanoma Cell Vaccine;
NCIt synonyms : GVAX Melanoma Vaccine;
NCIt definition : An allogeneic cancer vaccine composed of lethally irradiated whole melanoma cancer
cells that are genetically modified to secrete the immunostimulatory cytokine granulocyte-macrophage
colony-stimulating factor (GM-CSF), with potential immunostimulating and antineoplastic
activities. Upon intradermal injections, allogeneic GM-CSF-secreting lethally irradiated
whole melanoma cell vaccine secretes GM-CSF. In turn, GM-CSF may stimulate the body's
immune system against tumor cells by enhancing the activation of dendritic cells (DCs)
and promoting antigen presentation to both B- and T-lymphocytes. In addition, GM-CSF
promotes antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated
lymphokine-activated killer cell function.;
NCI Metathesaurus CUI : CL432401;
Origin ID : C98282;
UMLS CUI : C3273935;
Semantic type(s)
- concept_is_in_subset
