Preferred Label : CCL21-expressing H1944 Cell Vaccine;
NCIt synonyms : Recombinant Human 6C Cytokine-expressing H1944 Cell Vaccine;
NCIt definition : A cancer cell vaccine comprised of the allogeneic human lung adenocarcinoma cell line
H1944 that has been transduced ex vivo with adenoviral vector encoding human cytokine
chemokine C-C motif ligand 21 (CCL21), with potential immunomodulating and antineoplastic
activities. Upon administration, CCL21-expressing H1944 cell vaccine expresses the
chemokine CCL21, which may induce an antitumoral cytotoxic T-lymphocyte immune response
in the tumor microenvironment. CCL21 has been shown to attract antigen presenting
cells (APCs), like leukocytes and DCs, and natural killer (NK) cells and their T-cell
effectors to induce a cytotoxic immune response. H1944 cells contain tumor-associated
antigens (TAAs) overexpressed in non-small cell lung cancer (NSCLC).;
NCI Metathesaurus CUI : CL432400;
Origin ID : C98281;
UMLS CUI : C3273934;
Semantic type(s)
- concept_is_in_subset
