Opaganib - CISMeF

Preferred Label : Opaganib;

NCIt synonyms : SK2 inhibitor ABC294640; 4-Pyridinylmethyl-3-(4-chlorophenyl) Adamantane Carboxamide; Tricyclo(3.3.1.13,7)decane-1-carboxamide, 3-(4-Chlorophenyl)-N-(4-pyridinylmethyl)-;

NCIt definition : An orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, opaganib competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation. This may eventually lead to the induction of apoptosis and may result in an inhibition of cell proliferation in cancer cells overexpressing SK2. SK2 and its isoenzyme SK1 are overexpressed in numerous cancer cell types.;

UNII : DRG21OQ517;

InChIKey : CAOTVXGYTWCKQE-UHFFFAOYSA-N;

CAS number : 915385-81-8;

Drug name : Yeliva;

Molecule name : ABC294640; ABC 294640;

Details

Origin ID

C98278;

UMLS CUI

C2933331;

Currated CISMeF NLP mapping
- 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide [MeSH Supplementary Concept]
- 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide [MeSH Supplementary Concept]
- 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_target
- Sphingosine Kinase 2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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