Biguanide Antidiabetic Agent

Preferred Label : Biguanide Antidiabetic Agent;

NCIt related terms : Biguanide;

NCIt definition : Any antidiabetic agent with the biguanide base structure or phenformin derivatives with antihyperglycemic activity. Biguanide antidiabetic agents activate AMP-activated protein kinase (AMPK) resulting in decreased glucose production in the liver, increased peripheral glucose uptake and improved utilization of glucose. Biguanide-based antidiabetic agents do not cause hypoglycemia. In addition, biguanide antidiabetics decrease absorption of glucose from the gastrointestinal tract.;

Details

Origin ID

C98234;

UMLS CUI

C4317165;

Automatic exact mappings (from CISMeF team)
- biguanides [ATC Code]
- biguanides [MeSH concept]
- biguanides [ATC Code]
- biguanides [MeSH Descriptor]
- biguanides for the disinfection of medical devices [EMDN group]
Currated CISMeF NLP mapping
- Biguanide oral hypoglycemic agent (substance) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Biguanide (substance) [SNOMED CT concept]
- Product containing biguanide (product) [SNOMED CT concept]
Validated automatic mappings to NTBT
- Biguanide (substance) [SNOMED CT concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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