LHX4 wt Allele

Preferred Label : LHX4 wt Allele;

NCIt synonyms : CPHD4; FLJ22769; LIM Homeobox 4 wt Allele;

NCIt definition : Human LHX4 wild-type allele is located in the vicinity of 1q25.2 and is approximately 45 kb in length. This allele, which encodes LIM/homeobox protein Lhx4, is involved in the modulation of both pituitary development and transcription. Mutation of the gene is associated with combined pituitary hormone deficiency 4. A chromosomal translocation t(1;14)(q25;q32) of this gene and the IGHG1 gene is associated with pre-B acute lymphoblastic leukemia.;

GenBank Accession Number : AB037683;

Details

Origin ID

C98103;

UMLS CUI

C3273821;

Automatic exact mappings (from CISMeF team)
- Pituitary hormone deficiency, combined, 4 [OMIM Phenotype]
OMIM relation
- Lim homeobox gene 4 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 1q25.2 [NCIt concept]
gene_plays_role_in_process
- Cell Differentiation Process [NCIt concept]
- DNA Binding [NCIt concept]
- Developmental Process [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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