TLX3 wt Allele

Preferred Label : TLX3 wt Allele;

NCIt synonyms : T Cell Leukemia Homeobox 3 wt Allele; Homeo Box 11-Like 2 Gene; MGC29804; RNX; HOX11L2; T-Cell Leukemia, Homeobox 3 Gene; T-Cell Leukemia Homeobox 3 Gene;

NCIt definition : Human TLX3 wild-type allele is located in the vicinity of 5q35.1 and is approximately 3 kb in length. This allele, which encodes T-cell leukemia homeobox protein 3, may play a role in the regulation of transcription. T-cell leukemia is associated with mutation or aberrant expression of the gene and with at least two chromosomal translocations that include the gene. Translocation t(5;14)(q35;q32) fuses this gene and the BCL11B gene and translocation t(5;14)(q35;q11) fuses this gene with the T cell receptor delta locus.;

GenBank Accession Number : AJ223798;

Details

Origin ID

C98100;

UMLS CUI

C3273819;

Automatic exact mappings (from CISMeF team)
- T cell leukemia homeobox 3 [ORDO Gene]
- T-cell leukemia homeobox 3 [OMIM gene]
OMIM relation
- T-cell leukemia homeobox 3 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 5q35.1 [NCIt concept]
gene_involved_in_pathogenesis_of_disease
- T Acute Lymphoblastic Leukemia with TLX3 Rearrangement [NCIt concept]
gene_plays_role_in_process
- Cell Differentiation Process [NCIt concept]
- DNA Binding [NCIt concept]
- Developmental Process [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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