Preferred Label : Efinaconazole;
NCIt synonyms : (2R,3R)-2-(2,4-difluorofenil)-3-(4-metilenopiperidin-1-il)-1-(1h-1,2,4-triazin-1-il)butan-2-ol; 1-Piperidineethanol, alpha-(2,4-Difluorophenyl)-beta-methyl-4-methylene-alpha-(1H-1,2,4-triazol-1-
ylmethyl)-, (alphaR,betaR)-;
NCIt definition : A triazole compound, with antifungal activity. Upon administration, efinaconazole
targets, binds to and inhibits 14-alpha-demethylase, a cytochrome P450-dependent enzyme.
Inhibition of 14-alpha-demethylase prevents the conversion of lanosterol to ergosterol,
an important component of the fungal cell wall. Inhibition of ergosterol synthesis
changes the fungal cell membrane composition and integrity, alters membrane permeability
and eventually leads to fungal cell lysis.;
UNII : J82SB7FXWB;
InChIKey : NFEZZTICAUWDHU-RDTXWAMCSA-N;
CAS number : 164650-44-6;
Drug name : Jublia; Clenafin;
Molecule name : KP-103; KP 103;
Chemical formula : C18H22F2N4O;
Origin ID : C97998;
UMLS CUI : C3273754;
Automatic exact mappings (from CISMeF team)
- CISMeF manual mappings
- Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
