VEGFR2 Tyrosine Kinase Inhibitor PF-00337210

Preferred Label : VEGFR2 Tyrosine Kinase Inhibitor PF-00337210;

NCIt related terms : PF-337210;

NCIt definition : An orally available ATP-competitive inhibitor of the vascular endothelial growth factor receptor type 2 (VEGFR2), with potential anti-angiogenesis and antineoplastic activities. Upon administration, the VEGFR2 tyrosine kinase inhibitor PF-00337210 selectively binds to VEGFR2 and prevents its phosphorylation which may result in an inhibition of migration, proliferation and survival of endothelial cells, microvessel formation, the inhibition of tumor cell proliferation, and may eventually cause tumor cell death. VEGFR2, a receptor tyrosine kinase, is frequently overexpressed by a variety of tumor types.;

UNII : 3K3KYC9LES;

CAS number : 854514-88-8;

Molecule name : PF-00337210;

Details

Origin ID

C97950;

UMLS CUI

C3253799;

Currated CISMeF NLP mapping
- PF 00337210 [MeSH Supplementary Concept]
- PF 00337210 [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- PF 00337210 [MeSH concept]
- PF 00337210 [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Vascular Endothelial Growth Factor Receptor 2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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