Preferred Label : Ruthenium-based Transferrin Targeting Agent NKP-1339;
NCIt related terms : IT-139;
NCIt definition : A ruthenium-containing cancer agent targeting transferrin with potential antineoplastic
activity. Upon intravenous administration, NKP-1339 (Ru3 ) binds to transferrin (Tf)
and is taken up via Tf receptors (TfR), which are overexpressed on cancer cells. Once
inside the cell, NKP-1339 is released from Tf and is reduced, within the acidic environment
of the endosomes, to its active form NKP-119 (Ru2 ). In turn, the active form induces
a redox reaction, thereby leading to the formation of reactive oxygen species (ROS)
which inhibits GRP78 and SOD, endoplasmic reticulum-stress modulating molecules as
well as BAG4 and ERK, program cell death regulating molecules. This eventually induces
caspase-dependent apoptosis.;
UNII : 7OSJ9KS483;
CAS number : 197723-00-5;
Molecule name : NKP-1339;
Origin ID : C97948;
UMLS CUI : C3273716;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
