Preferred Label : Glycooptimized Trastuzumab-GEX;
NCIt synonyms : Ant-HER2 Monoclonal Antibody GT-Mab 7.3-GEX; GT-Mab 7.3-GEX;
NCIt definition : A glycoengineered form of a monoclonal antibody directed against the human epidermal
growth factor receptor-2 (HER2), with potential antineoplastic activity. Glycooptimized
trastuzumab-GEX specifically binds to the extracellular domain of HER2, thereby inducing
an antibody-dependent cell-mediated cytotoxicity (ADCC) against HER2-expressing tumor
cells. This eventually results in apoptosis and growth inhibition of tumor cells.
HER2, a member of the receptor tyrosine kinase EGFR superfamily, is overexpressed
on the cell surfaces of various solid tumors. This agent has a specific glycosylation
profile that may enhance its ADCC response against HER2-expressing tumor cells.;
Drug name : TrasGEX;
NCI Metathesaurus CUI : CL430400;
Origin ID : C97917;
UMLS CUI : C3273695;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
