PCM1 wt Allele

Preferred Label : PCM1 wt Allele;

NCIt synonyms : Pericentriolar Material 1 wt Allele; PTC4;

NCIt definition : Human PCM1 wild-type allele is located within 8p22-p21.3 and is approximately 107 kb in length. This allele, which encodes pericentriolar material 1 protein, plays a role in the regulation of centrosome formation. A chromosomal translocation t(8;10)(p21.3;q11.2) of this gene and the RET gene is associated with papillary thyroid carcinoma. A second translocation t(8;9)(p22;p24) of this gene and the JAK2 gene is found in a variety of hematological malignancies including atypical chronic myeloid leukemia and T-cell lymphoma.;

GenBank Accession Number : NM_006197;

Details

Origin ID

C97901;

UMLS CUI

C3273684;

OMIM relation
- Pericentriolar material 1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 8p22-p21.3 [NCIt concept]
gene_plays_role_in_process
- Cell Movement Process [NCIt concept]
- Cytoskeletal Process [NCIt concept]
- G2 to M Transition Process [NCIt concept]
- Microtubule Polymerization Process [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Regulation of Cell Shape [NCIt concept]

Keyword's position in hierarchy(ies) :

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