NCIt definition : A fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil
(5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation
of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU
in the presence of pyrimidine nucleoside phosphorylase. 5-FU interferes with DNA synthesis
and subsequent cell division by reducing normal thymidine production and interferes
with RNA transcription by competing with uridine triphosphate for incorporation into
the RNA strand.;
UNII : V1JK16Y2JP;
InChIKey : ZWAOHEXOSAUJHY-ZIYNGMLESA-N;
CAS number : 3094-09-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 3094-09-5
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