Doxifluridine - CISMeF

Preferred Label : Doxifluridine;

NCIt synonyms : 5'-Deoxy-5-fluorouridine; 5-DFUR;

NCIt definition : A fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase. 5-FU interferes with DNA synthesis and subsequent cell division by reducing normal thymidine production and interferes with RNA transcription by competing with uridine triphosphate for incorporation into the RNA strand.;

UNII : V1JK16Y2JP;

InChIKey : ZWAOHEXOSAUJHY-ZIYNGMLESA-N;

CAS number : 3094-09-5;

Chemical formula : C9H11FN2O5;

Codes from synonyms : 169;

Details

Origin ID

C978;

UMLS CUI

C0048808;

Automatic exact mappings (from CISMeF team)
- Doxifluridine [ICHI extension code]
Currated CISMeF NLP mapping
- Doxifluridine [ICD-11 Extension code]
- doxifluridine [Substance BNPC]
- doxifluridine [MeSH concept]
- doxifluridine [MeSH Supplementary Concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Doxifluridine [ICD-11 Extension code]
- doxifluridine [Substance BNPC]
- doxifluridine [MeSH concept]
- doxifluridine [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Doxifluridine/L-Leucovorin [NCIt concept]

Keyword's position in hierarchy(ies) :

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