Ansamitomicin P-3

Preferred Label : Ansamitomicin P-3;

NCIt synonyms : Maytansine, 3-o-de(2-(acetylmethylamino)-1-oxopropyl)-3-o-(1-oxobutyl)-;

NCIt definition : An ansamacrolide and maytansine analogue originally isolated from the Ethiopian shrub Maytenus serrata with antineoplastic activity. Ansamitomicin P-3 binds to tubulin at the maytansine-binding site, thereby inhibiting microtubule assembly, inducing microtubule disassembly, and disrupting mitosis.;

UNII : 7SUK7876BG;

InChIKey : OPQNCARIZFLNLF-JBHFWYGFSA-N;

CAS number : 66547-09-9;

Chemical formula : C32H43ClN2O9;

Details

Origin ID

C97710;

UMLS CUI

C0952781;

Automatic exact mappings (from CISMeF team)
- Ansamitomicin p-3 [SMS substance]
- ansamitocins [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ansamitocin P 3 [MeSH concept]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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