Preferred Label : Sam68 Modulator CWP232291;
NCIt definition : A small molecule and prodrug of CWP232204 targeting Src associated in mitosis, of
68 kDa (Sam68 or KHDRBS1), with potential antineoplastic activity. CWP232291 is converted
in serum into its active form CWP232204 which binds to Sam68, thereby resulting in
the induction of apoptosis in selective cancer cells. Due to the multimodular structure
of Sam68, the apoptosis mediated by CWP232204-Sam68 interaction can attribute from
1) activation of transcription factor NF-kB induced by tumor necrosis factor alpha
signaling, 2) alternative splicing of BCL-2 apoptosis gene, driving the balance towards
pro-apoptotic as opposed to anti-apoptotic isoforms, 3) down-regulation of the anti-apoptotic
protein survivin via Wnt signaling. Sam68, a KH domain RNA-binding protein belonging
to the signal transduction and activation of RNA (STAR) family, plays a key role in
various cellular processes including cell cycle progression and apoptosis; it is upregulated
in many types of cancer cells and its expression is associated with increased cell
proliferation and survival.;
Molecule name : CWP232291;
NCI Metathesaurus CUI : CL430318;
Origin ID : C97663;
UMLS CUI : C3273553;
Semantic type(s)
- concept_is_in_subset
- has_target
