NCIt definition : Human LPP wild-type allele is located in the vicinity of 3q28 and is approximately
737 kb in length. This allele, which encodes lipoma-preferred partner protein, may
play a role in cell motility and cell shape. A chromosomal translocation t(3;12)(q27-q28;q13-q15)
of this gene with the HMGA2 gene is associated with lipoma and translocation t(3;11)(q28;q23)
of this gene with the MLL gene is associated with acute monoblastic leukemia.;
NCIt note : The LPP and HMGA2 genes are involved in other chromosomal aberrations; t(3;12)(q27-q28;q14-q15)
is associated with pulmonary chondroid hamartoma and t(3;12)(q28;q14) is associated
with a rare disease, parosteal lipoma.;